• Patients and families

• Health professionals

• Contacts

• Links

Information for health care professionals

• Home
• Newborn screening
• Diagnosis
• Airway cultures
• Staph aureus MSSA
• MRSA
• Pseudomonas
• Cepacia
• NTM
• Infection control
• Oral antibiotics
• Intravenous antibiotics
• Hearing loss
• Inhaled antibiotics
• DNase and HS
• Pancreatic enzymes
• Vitamin supplements
• Low vitamin D
• Salt supplements
• ABPA
• Bone disease
• CFRD
• DIOS
• Haemoptysis
• Liver disease
• Meconium ileus
• Transition

Staphylococcus aureus (MSSA)

All children should be started on flucloxacillin 125mg bd from diagnosis until the 3rd birthday. If recurrent MSSA infection has not been an issue, the flucloxacillin should be stopped on the 3rd birthday (not the second as we have previously done). If children do not tolerate flucloxacillin, no prophylaxis should be given - we do not recommend using an alternative broader spectrum antibiotic since these may increase risk of early Pseudomonas.

If there have been 3 or more positive cultures for MSSA in any 12 month period, then the twice daily prophylaxis should either continue or be commenced (at any age). See 'oral antibiotics for dosage'. If children do not tolerate flucloxacillin, no prophylaxis should be given - we do not recommend using an alternative broader spectrum antibiotic since these may increase risk of early Pseudomonas.

If MSSA grows while the patient is receiving flucloxacillin, consider patient adherence and increase the flucloxacillin to treatment dose (tds - see oral antibiotics for dosage) and ADD a second oral anti-staphylococcal antibiotic for two to four weeks (sodium fusidate, or rifampicin).